Effect Of Diazepam And Tramadol On Some Biochemical Parameters In Male Rabbits

Abstract

This study aimed at investigating the impact of Diazepam and Tramadol  on serum liver enzyme, oxidative stressm and som antioxidant markers in male rabitts. A total of 20 growing rabbits (7.5 weeks old) reared under high ambient temperature were divided into two equal groups, 10 rabbits each. The first group control dministered with normal saline and the second group Diazepam and Tramadol-treated rats (50 mg/kg b.w. orally) for 30. Blood samples were withdrawn to measure serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), Glutathione (GSH), malondialdehyde (MDA) levels and catalase (CAT), activities were assayed. In Diazepam and Tramadol -treated group, significant increases in aspartate aminotransferases,and alanin aminotransferases  activities, malondialdehyde (MDA) levels and significant decreases in catalase (CAT), glutathione activities levels were determined compared to the control group. Diazepam and Tramadol  administration produces noticeable biochemical changes in a dosedependent manner associated with increased liver enzyme and oxidative stress markers and decreased antioxidative activity.